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KMID : 0379520010170040317
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한국독성학회지
2001 Volume.17 No. 4 p.317 ~ p.323
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Dermal Penetration Rate and Pharmacokinetics of the Insecticide Methidathion in Sprague-Dawley Rats
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Sung Ha-Jung
Kim Jeong-Han
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Abstract
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The skin penetration rate of methidathion in vitro and pharmacokinetics of methidathion in vivo were studied with male Sprague-Dawley rats by dermal treatment. The in vitro skin penetration rates for Sprague-Dawley rats of methidathion technical (50 mg, 100 {mu}ell) and emulsifable concentrate (EC,40mg, 100{mu}ell) were determined as 18.4 mutextrm{g}/c m^2/h (RSD : 6.5) and 18.5 mutextrm{g}/c m^2/h (RSD : 3.2), respectively. Dose-related systemic exposure (AUC) was observed in rats after dermal treatment. The corresponding AUC, T_{max}, C_{max}, and T_{1}2/ of methidathion in plasma were 1.5mutextrm{g}.hr/ml, 6 h, 0.10 mutextrm{g}/ml, and 16 h, for 116mg/kg doses, 3.2 mutextrm{g}. hr/ml, 8 h, 0.12 mutextrm{g}/ml, and 23 h, for 232 mg/kg doses and 10 mutextrm{g}. hr/ml, 12 h, 0.32 mutextrm{g}/ml, and 20 h, for 1,160 mg/kg doses respectively. The urinary excretion of methidathion, estimated wing an equation derived from the in vitro skin penetration study was 0.24~0.35% of the absorbed dose. The concentration of methidathion in kidney was higher than that in liver. Dose-dependent absorption and excretion of methidathion without saturation was observed under in vivo experimental condition.n.n.
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KEYWORD
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Methidathion, Penetration rate, Skin, Blood, Excretion
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